Adelaide skipper Taylor Walker is set to return to the AFL after recovering from an ankle complaint.
Walker missed Sunday's 82-point thumping of Essendon after pulling up sore in the dying minutes of the Crows' round 18 clash with Geelong.
The 26-year-old spent time in a moonboot but was cleared of serious damage and is expected to play against Brisbane on Saturday night.
"He did a light session this morning," Pyke said after Sunday's game.
"I think he'll be up running probably as early as tomorrow.
"He has no soreness at the moment which is great so we'd hope he'll train for us Wednesday and be ready to go next week."
The Crows are also confident valuable ruckman Sam Jacobs has avoided serious injury after hurting his left ankle against Essendon.
The 202cm veteran landed awkwardly during a marking contest early in the second quarter of the 22.11 (143) to 9.7 (61) win at Adelaide Oval.
Jacobs didn't return to the field and later emerged on crutches.
"The report at the moment is it's a low-grade strain," Pyke said.
"Once he came off, the decision from the doctor was probably a no-risk policy which is wise in the circumstances.
"Hopefully he can rehab that and give himself every chance next week."
Key forward Josh Jenkins filled in for Jacobs against Essendon but was solidly beaten by Matthew Leuenberger, who finished with 53 hitouts.
Pyke said he would consider sticking with Jenkins if Jacobs was unavailable, with untested rookie Reilly O'Brien a chance to make his debut.